Search results for "methods [Biological Assay]"

La circulation des objets métalliques à l'âge du Bronze entre Rhône et Saône: utilisation d'une transformation cartographique linéaire

2006

In order to gain a better understanding of circulation flows of metal objects during the Bronze Age, and move beyond traditional distribution maps of archaeological discoveries, the authors propose a more quantitative and concise method of graphic representation, namely cartographic linear transformation. The value of the method was tested on the Saône-Rhône axis. Bronze axes, swords and daggers were recorded along a 50 km strip either side of the river axis, in order to estimate the frequency and mass of objects in “circulation”.

The Rise and Fall of Business Firms: A Stochastic Framework on Innovation, Creative

2021

FPGA implementation of a deep learning algorithm for real-time signal reconstruction in particle detectors under high pile-up conditions

2019

The analog signals generated in the read-out electronics of particle detectors are shaped prior to the digitization in order to improve the signal to noise ratio (SNR). The real amplitude of the analog signal is then obtained using digital filters, which provides information about the energy deposited in the detector. The classical digital filters have a good performance in ideal situations with Gaussian electronic noise and no pulse shape distortion. However, high-energy particle colliders, such as the Large Hadron Collider (LHC) at CERN, can produce multiple simultaneous events, which produce signal pileup. The performance of classical digital filters deteriorates in these conditions sinc…

Devenir chercheur ou enseignant chercheur : le goût pour la recherche des doctorants à l'épreuve du marché du travail

2016

Faire une thèse pour devenir chercheur ou enseignant-chercheur est souvent considéré comme un parcours difficile dont le résultat est incertain. Plus que dans d’autres pays, les diplômés de doctorat en France connaissent de fortes difficultés de stabilisation sur le marché du travail. Notre recherche s’interroge sur les raisons qui conduisent les jeunes à obtenir un doctorat puis à choisir une carrière de chercheur ou d’enseignant-chercheur et enfin, à s’y stabiliser. À partir d’une enquête du Céreq, nos résultats montrent que l’intérêt pour la recherche qu’ils ont manifesté dès le début des études supérieures et le capital social vont fortement structurer leur parcours universitaire et pro…

Absolute and relative quantification of RNA modifications via biosynthetic isotopomers

2014

In the resurging field of RNA modifications, quantification is a bottleneck blocking many exciting avenues. With currently over 150 known nucleoside alterations, detection and quantification methods must encompass multiple modifications for a comprehensive profile. LC-MS/MS approaches offer a perspective for comprehensive parallel quantification of all the various modifications found in total RNA of a given organism. By feeding (13)C-glucose as sole carbon source, we have generated a stable isotope-labeled internal standard (SIL-IS) for bacterial RNA, which facilitates relative comparison of all modifications. While conventional SIL-IS approaches require the chemical synthesis of single mod…

Computational identification of cell-specific variable regions in ChIP-seq data.

2019

ABSTRACT Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is used to identify genome-wide DNA regions bound by proteins. Several sources of variation can affect the reproducibility of a particular ChIP-seq assay, which can lead to a misinterpretation of where the protein under investigation binds to the genome in a particular cell type. Given one ChIP-seq experiment with replicates, binding sites not observed in all the replicates will usually be interpreted as noise and discarded. However, the recent discovery of high-occupancy target (HOT) regions suggests that there are regions where binding of multiple transcription factors can be identified. To investigate these regions,…

Reflections on Connectionist Modeling

2018

International audience

Stochastic analysis of dynamical systems with delayed control forces

2006

Abstract Reduction of structural vibration in actively controlled dynamical system is usually performed by means of convenient control forces dependent of the dynamic response. In this paper the existent studies will be extended to dynamical systems subjected to non-normal delta-correlated random process with delayed control forces. Taylor series expansion of the control forces has been introduced and the statistics of the dynamical response have been obtained by means of the extended Ito differential rule. Numerical application provided shows the capabilities of the proposed method to analyze stochastic dynamic systems with delayed actions under delta-correlated process contrasting statist…

Burst analysis tool for developing neuronal networks exhibiting highly varying action potential dynamics

2012

In this paper we propose a firing statistics based neuronal network burst detection algorithm for neuronal networks exhibiting highly variable action potential dynamics. Electrical activity of neuronal networks is generally analyzed by the occurrences of spikes and bursts both in time and space. Commonly accepted analysis tools employ burst detection algorithms based on predefined criteria. However, maturing neuronal networks, such as those originating from human embryonic stem cells (hESC), exhibit highly variable network structure and time-varying dynamics. To explore the developing burst/spike activities of such networks, we propose a burst detection algorithm which utilizes the firing s…

Modelling thermionic emission by using a two Level mechanical system

2008

The Boltzmann factor is at the basis of a great amount of thermodynamic and statistical physics, both classical and quantum. It describes the behaviour of natural systems that exchange energy with the environment. However, why does the expression have that specific form? The Feynman Lectures on Physics justifies it heuristically by referencing to the "exponential atmosphere" example. Thermodynamics textbooks usually give a more or less complete explanation that mainly involves a mathematical analysis, where it is hard to see the logic flow. Moreover, the necessary mathematics is not at the level of high school or college students' preparation. Here we present an experiment and a simulation …